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doi: 10.1186/1532-429X-10-42

[4] The synthesis of thyroid hormones T3 and T4 begin with the production and release of the tripeptide Thyrotropin Releasing Hormone (TRH) from the paraventricular nucleus of the hypothalamus within the brain

By inhibiting NNMT, 5-Amino-1MQ essentially removes a metabolic brake, allowing the body to burn fat more efficiently and maintain healthier NAD+ levels